1. Targeted therapy guided by single-cell transcriptomic analysis ...
Jan 20, 2020 · To model culprit drug-induced immune responses, we utilized the lymphocyte transformation test (LTT), which reliably measures drug-induced T ...
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS) is a potentially fatal multiorgan inflammatory disease associated with herpesvirus reactivation and subsequent onset of autoimmune diseases1–4. Pathophysiology remains elusive and therapeutic options are limited. Cases refractory to corticosteroid therapy pose a clinical challenge1,5 and approximately 30% of patients with DiHS/DRESS develop complications, including infections and inflammatory and autoimmune diseases1,2,5. Progress in single-cell RNA sequencing (scRNA-seq) provides an opportunity to dissect human disease pathophysiology at unprecedented resolutions6, particularly in diseases lacking animal models, such as DiHS/DRESS. We performed scRNA-seq on skin and blood from a patient with refractory DiHS/DRESS, identifying the JAK–STAT signaling pathway as a potential target. We further showed that central memory CD4+ T cells were enriched with DNA from human herpesvirus 6b. Intervention via tofacitinib enabled disease control and tapering of other immunosuppressive agents. Tofacitinib, as well as antiviral agents, suppressed culprit-induced T cell proliferation in vitro, further supporting the roles of the JAK–STAT pathway and herpesviruses in mediating the adverse drug reaction. Thus, scRNA-seq analyses guided successful therapeutic intervention in the patient with refractory DiHS/DRESS. scRNA-seq may improve our understanding of complicated human disease pathophysi...

2. SpicyPotato (aikhaterine) - 악인전기 | Evilive (TV) [Archive of Our Own]
6 hours ago · What had never happened was the doctor leaving without first administering the drugs to Doyoung. He wanted to laugh, but at the same time ...
An Archive of Our Own, a project of the Organization for Transformative Works
3. Public Enemy Number One: A Pragmatic Approach to America's ...
Jun 29, 2016 · Caution must be heeded when confronted with the popular perception of Nixon's “war on drugs.” It has been blamed, rather unfairly, for steering ...
At a press conference on June 17, 1971, President Nixon, with his newly appointed Drug authority at his side, declared drug abuse “public enemy number one.” “In order to fight […]

4. Bogotá: A Grand Tale of Survival and Desire in a Foreign Land [Review]
Dec 31, 2024 · Breaking away from typical crime drama tropes of drug trafficking, 'Bogotá' focuses on clothing smuggling, offering a fresh narrative approach.
The film 'Bogotá: The Land of Last Opportunities' (보고타: 마지막 기회의 땅) vividly portrays the fierce power struggles within a Korean immigrant community in South Ame
![Bogotá: A Grand Tale of Survival and Desire in a Foreign Land [Review]](https://cdn.k-ennews.com/news/thumbnail/202412/6281_16937_1747_v150.jpg)
5. Chapter 69.41 RCW: LEGEND DRUGS—PRESCRIPTION DRUGS
Sale, delivery, possession, or use of legend drug without prescription or order prohibited—Exceptions—Penalty—Referral to assessment and services. HTMLPDF ...
Complete ChapterHTML PDF | RCW Dispositions
6. todorokitouya - Bookmarks | Archive of Our Own
Glancing down at the bright pill in the palm of his hand, small and cheerfully innocuous looking, Leon felt a flicker of doubt lick up his spine.
An Archive of Our Own, a project of the Organization for Transformative Works
7. Anne Hathaway Once Revealed She Was 'Not Excited' About 'Making Out ...
6 days ago · Yes, think back to her royal spark with Robert Schwartzman in The Princess Diaries or her steamy bond with Jake Gyllenhaal in Love & Other Drugs ...
Anne Hathaway’s Hollywood career is brimming with onscreen chemistry. But, did these come with a rather heavy cost? Read on for more.

8. 'Squid Game 2' Director Hwang Dong-hyuk Defends T.O.P Amid ...
Jan 1, 2025 · Hwang elaborated on T.O.P's role as Richter "Thanos," describing the character as "a rapper and drug addict." He added, "For T.O.P, this ...
Amid heated debate over the casting of Choi Seung-hyun (최승현 T.O.P 탑) in the second season of 'Squid Game' (오징어게임), director Hwang Dong-hyuk (황동혁) has openly su

9. Overview of Drug Courts | National Institute of Justice
Drug courts are specialized court docket programs that target criminal defendants, juveniles who have been convicted of a drug offense, and parents with pending ...
NIJ Seeks Research Partner Sites for Veterans Treatment Court Evaluation NIJ seeks programs that are interested in participating in the NIJ Multisite Impact and Cost -Efficiency Evaluation of Veterans Treatment Courts.

10. Find artists that start with D - SportsChosun
Find out the latest news on your favorite artists who beginning with the letter D in Sports Chosun.
11. List of every male kpop idol - kpopping
Doyoung ( NCT 127 , NCT U , NCT , NCT DOJAEJUNG ). Doyoung ( TREASURE , T5 ). Doyul ( 14U , D-One ). DPR ARTIC · DPR CREAM · DPR IAN ( C-CLOWN ). Drok. Q ( Drug ...
List of every male kpop idol and links to their profile pages
12. World Drug Report 2006 - United Nations Office on Drugs and Crime
The World Drug Report 2006 endeavours to fill this gap. It provides one of the most comprehensive overviews of illicit drug trends at the international level.
WDR 2006
13. Find artists that start with D - SportsChosun
Find out the latest news on your favorite artists who beginning with the letter D in Sports Chosun.
14. Fifty Years Ago Today, President Nixon Declared the War on Drugs
Fifty years after then-President Richard Nixon declared a “war on drugs,” the United States is still mired in the implications of this wrongheaded, racist ...
Today, police make more than 1.5 million drug arrests each year , and about 550,000 of those are for cannabis offenses alone. Almost 500,000 people are incarcerated for nothing more than a drug law violation, and Black and brown people are disproportionately impacted by drug enforcement and…
